Congenital Deafness in Dogs. Effect of Patch On Deafness Prevalence 0 10 20 30 40 50 60 70 80 90 100.
Waardenburg syndrome - Genetics Home Reference. Mutations in the EDN3, EDNRB, MITF, PAX3, SNAI2, and SOX1.
Info about White Boxers. Regarding deafness, the genetic basis of white in Boxers is the same as inDalmatians.
Waardenburg syndrome. These genes are involved in the formation and development of several types of cells, including pigment- producing cells called melanocytes.
Melanocytes make a pigment called melanin, which contributes to skin, hair, and eye color and plays an essential role in the normal function of the inner ear. Mutations in any of these genes disrupt the normal development of melanocytes, leading to abnormal pigmentation of the skin, hair, and eyes and problems with hearing. Waardenburg syndrome types I and III are caused by mutations in the PAX3 gene. Mutations in the MITF or SNAI2 gene can cause Waardenburg syndrome type II.
Mutations in the SOX1. EDN3, or EDNRB gene can cause Waardenburg syndrome type IV. In addition to melanocyte development, these genes are important for the development of nerve cells in the large intestine. Mutations in one of these genes result in hearing loss, changes in pigmentation, and intestinal problems related to Hirschsprung disease. In some cases, the genetic cause of Waardenburg syndrome has not been identified.
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WHITE CATS, EYE COLOURS AND DEAFNESS. There is a known link between white coat color, blue eyes and deafness - but since the coat and eye color can be caused by different genes it means that only some blue eyed whites are deaf. A forelock of white hair, or. Deafness (more common in type II disease) Extremely pale blue eyes or eye colors that don't match. White patch of hair or early graying of the hair; Less common types of this disease may cause problems with the arms or.